Dr. Gregory House (Hugh Laurie) is devoid of bedside manner and wouldn't even talk to his patients if he could get away with it. Dealing with his own constant physical pain, he uses a cane that seems to punctuate his acerbic, brutally honest demeanor. While his behavior can border on antisocial, House is a maverick physician whose unconventional thinking and flawless instincts have afforded him a great deal of respect. An infectious disease specialist, he's a brilliant diagnostician who loves the challenges of the medical puzzles he must solve in order to save lives.

In this show,  the villain is a medical malady and hero is an irreverent, controversial doctor who trusts no one, least of all his patients.

http://www.tv.com/House/show/22374/summary.html

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cynical
weather-beaten 
freaky
self-centered
conceited